Stem Cell Implantation to Jugular Veins at the time of Liberation Therapy Supports Long-term Patency, Neuronal Regeneration

Sep 16, 2012 No Comments by

While some MS patients who have had the liberation therapy are reporting long-term benefits from having the procedure, there are just as many for whom the ‘liberation therapy’ has failed as an effective therapeutic intervention. This doesn’t mean that these patients didn’t have some immediate benefits once the neck veins were opened; most did, but over time the veins restenosed again and their MS symptoms returned. In fact, having seen their MS symptoms almost totally disappear however briefly once their veins were cleared, patients who have restenosed want it done over again, as many times as necessary in some cases. However, there is now a new and growing subset of MS patients who have had vein widening venoplasty multiple times, usually to less beneficial effect each time, leading to the later discovery of so much intraluminal scar tissue by the second, third, or fourth attempt at re-opening the veins that the procedure cannot be performed again.

Topical amongst this group are: vascular grafts, bioprosthetics with autologous source endothelialization, pig’s veins, etc. The need to remove jugular veins and implant new vessels because they are so occluded, indicates the possibility that there was ‘overtreatment’ of the veins during the initial venoplasty procedure that eventually led to the formation of scar tissue (that is, if they didn’t occlude with thrombin build-up (clots) immediately post-procedure). It’s well-known that once balloons are expanded in those narrowed areas of the diseased neck veins, tearing and abrasion (desquamation) occurs intraluminally causing inflammation and bleeding. And healing within venous lumen damaged due to venoplasty typically takes many months and leaves lasting, lumen-choking scars. Lumen diameters are permanently decreased. The recent self-reporting of an alarming number of permanently blocked neck veins certainly begs the question to be asked as to what additional medical interventions need to be developed to avoid this kind of catastrophic damage.

Because the definite risk exists that veins will become blocked as a result of the liberation therapy, this further indicates that there may not be recognition by the surgeons of the fragility of the neck vein structure, especially in patients that already have diagnosed venous disease (CCSVI), even though the procedure is considered to be ‘minimally invasive’. No additional steps in the current liberation therapy protocol have either been taken or proposed by Interventional Radiologists performing the vein dilation to eliminate the risk of restenosis. To date the approach amongst the Interventional Radiologists who are performing this therapy on an outpatient basis has been: ‘whatever happens, happens’, post-procedure. It is incorrectly assumed that restenosis will always be ‘correctable’ in subsequent therapies if necessary. This is now clearly proving to be the wrong assumption.

Therefore performing additional effective therapeutic modalities that will avoid the normal cascade of healing events and consequential scarring in support the liberation therapy is vitally important to restore and maintain optimal central nervous system (CNS) drainage once the abnormal veins have been widened. Preliminary evidence from CCSVI Clinic patient case reports indicates that stromal cells injected through the catheter at the time of the venoplasty and applied directly to the damaged vein avoid the formation of both thrombin and scar tissue intraluminally, and that the veins heal very quickly with no evidence of scar tissue. After over a year of treating patients’ veins with stem cells at the time of the liberation therapy, it may be hypothesized that the stem cells work to create more stable, stronger and more enduring veins resulting in long-term patency (optimal blood flow) and the subsequent avoidance of additional venoplasty procedures. Case studies on each patient treated with the combination therapy are now underway.

David Summers of Murfreesboro, TN is one such MS patient now being case studied. David came to the CCSVI Clinic as a paraplegic MS patient evaluated at 8.0 on the Kurtzke EDSS scale. His MS had become secondary progressive and his rate of deterioration had increased dramatically by late 2011. In April of 2012, David was treated at CCSVI Clinic with the combination liberation/autologous stem cell therapy protocol developed by researchers at Regenetek Cellular Technologies. Liberation therapy was first performed and adult autologous stem cells were implanted into David’s jugular veins at the time of his vein expansion. Four days later, a clinical dose of mesenchymal stem cells (MSCs), enhanced in vitro from the original autologous marrow source was implanted back into David’s CNS via lumbar puncture. (Stem cells multiplied from an autologous source not only ensures that patients are receiving their own DNA, but studies have shown there is no risk of cell mutation resulting in the formation of cancerous cells).

David’s MS symptoms not only began to improve immediately, but within four hours of his implantation, he began to feel sensation below the waist. This did not happen the first time he had his liberation therapy in 2010, nor in the 90 days following that procedure, the length of time that he said he had received some benefit as a result.

Following the combination of stem cell implants at CCSVI Clinic, disappearance of his MS symptoms could possibly be explained by the liberation therapy, but his subsequent nerve and muscle regeneration over the last several months can only be accounted for by the rebuilding of  the myelin and axonal fibers within the CNS. Only the implantation of pluripotent MSCs that can differentiate into neuroprogenitor cells can do this. Furthermore following his therapy, his frequent attacks of MS completely stopped, another known benefit of MSCs which express chemicals that ‘turn off’ the proteins expressed by the over-aggressive immune system attacking the CNS.

In the six months following his combination therapy at CCSVI Clinic, David began to walk and workout more frequently. At 108 days post-procedure he entered a formal physiotherapy program to improve his walking ability, balance and physical endurance. He has not had an MS attack since his therapies in April of 2012 and most of his MS symptoms have disappeared or reduced dramatically. His EDSS score has moved from an 8.0 to approximately 3.0 and he continues to improve.

Other MS patients not nearly as disabled as David was, having been treated at CCSVI Clinic, are now reporting dramatic improvement and many are now asymptomatic. This combination therapy protocol, meticulously researched and based on various clinical studies on autologous stem cell transplantation, has now been taken from the bench to the bedside for the first time. So far David Summers is one of dozens for whom the outcomes are producing therapeutically what the clinical studies have confirmed. More case study data is being produced and will make up the Prospective Cohort Study to be published later next year.

For more information on the combination therapy protocol and study email to apply@ccsviclinic.ca or call 888-468-1554.

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About the author

Doug Broeska is a PhD Medical Researcher and CEO of Regenetek Inc, a Canadian Biotech Research firm working with several hospitals and clinics world-wide to develop medical procedural protocols for neurodegenerative disease management.
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